· The Southern Ohio Conference was established in 1946
· The original charter members of the league were Central Catholic HS (Notre Dame), Glenwood HS (New Boston), Portsmouth East HS, Washington Township HS (Portsmouth West), and Waverly HS
· Minford High School joined the league in 1947 for basketball only
· In 1948 Chesapeake joined league for track only, South Point joined for baseball and track only, and Minford began play in baseball
· Wheelersburg & Dawson Bryant (Coal Grove) joined the league in 1950
· In 1951 South Point withdrew from the league
· Coal Grove withdrew from the league in 1952
· Central Catholic HS became Notre Dame High School in 1952
· Chesapeake withdrew from the league in 1954
· Piketon entered the conference in 1959 and then left in 1962
· Minford withdrew from the league in 1958 only to rejoin the league the next year
· Lucasville Valley joined the conference in 1958
· In 1960 McDermott Northwest entered league play
· Waverly withdrew from the SOC after the 1969-70 season
· In 1979 Clay, Green, & South Webster joined the league and the SOC went to two divisions
· Eastern (Pike) entered the conference in 1981
· Ironton St. Joe joined the league in 1982, withdrew in 1989, & rejoined in 2019
· In 1983 Waverly re-entered conference play
· Oak Hill & Symmes Valley both entered the league in 1991 (began play w/1992-93 season)
· Western (Pike) left the Southern Hills League and joined the SOC in 2002
· Portsmouth East becomes Sciotoville Community School (East Jr.-Sr.High School) in 2002
- Ironton Saint Joseph Central rejoined the conference in 2019
- SOC Division I: Clay, East (Sciotoville), Glenwood, Green, Notre Dame, Saint Joseph, Symmes Valley, & Western
- SOC Division II: Eastern (DI football), Minford, Northwest (DI football), Oak Hill, Portsmouth West, South Webster (DI golf), Valley (DI soccer), Waverly, & Wheelersburg
- South Gallia will leave the TVC and join the conference in 2023.
Member Schools & Years as Members of the Southern Ohio Conference
Chesapeake 1948-1954
Coal Grove (Dawson Bryant) 1950-1952
Clay 1979-present
East (Sciotoville) 1946-present
Eastern (Pike) 1981-present
Glenwood (New Boston) 1946-present
Green 1979-present
Ironton Saint Joseph 1982-1989 & 2019-present
Minford 1947-1958 & 1959-present
Northwest 1960-present
Oak Hill 1991-present
Piketon 1959-1962
Portsmouth Notre Dame (Central Catholic) 1946- present
Portsmouth West (Washington Township) 1946-present
South Point 1948-1951
South Webster 1979-present
Symmes Valley 1991-present
Valley 1958-present
Waverly 1946-1970 & 1983-present
Western (Pike) 2002-present
Wheelersburg 1950-present